SPIE. Digital Library – 23rd International Conference on Optical Fibre Sensors
2014
Celiac disease biodetection using lossy-mode resonances generated in tapered single-mode optical fibers
A.B. SOCORRO; J.M. CORRES; I. DEL VILLAR; I.R. MATIAS; F.J. ARREGUI

Abstract

This work presents the development and test of an anti-gliadin antibodies biosensor based on lossy mode resonances (LMRs) to detect celiac disease. Several polyelectrolites were used to perform layer-by-layer assembly processes in order to generate the LMR and to fabricate a gliadin-embedded thin-film. The LMR shifted 20 nm when immersed in a 5 ppm anti-gliadin antibodies-PBS solution, what makes this bioprobe suitable for detecting celiac disease. This is the first time, to our knowledge, that LMRs are used to detect celiac disease and these results suppose promising prospects on the use of such phenomena as biological detectors.

Keywords: Thin films; Single mode fibers; Optical Fibers; Biosensors; Sensors; Adsorption; Geometrical optics; Biosensing; Multimode Fibers; Radio propagation